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great tips. thanks! Thank you so much for 250+ Card Vectors | Download Art the advice! It's really helpful to know these things. Great advice Im gonna download that now :) I am off to download the plan.

Thanks for a very valuable perspective. great tips! i love the book finds too! xox. awesome tips! Thank you so much. :) Great post! I'll be working on my business plan very soon.

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Just what I needed1 A kick in the pants! Thank you. I know what I am doing this afternoon! so helpful, thank you. Zoe. i need this thank you -rose. Great!! I downloaded it already! ;-) Very helpful!! Thank you! This is exactly the kind of guidance I need.

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One of my goals is to get a solid business plan in place this year. Good tips! Relatively new to the blogs..any ideas for getting word about your shop out? This is great, and I love the workbook download. Thank you!

Thank you everyone for the sweet comments. And a big Thank You to Daniellexo for inviting me to post on Etsy's blog. EliteArtisans, for getting the word out about your shop, social media works well-- blogging, facebook, twitter. Thank! You might also join a team! Treasury or otherwise. Also, you might think about contacting bloggers and asking them to write about you. Good luck with your shop! And convo or email me anytime and let me know what topics you'd like to see on 8+ Records Form | Resume Wonder Thinking! :) --Tricia. Thanks for sharing.

I have a business as a wedding planner. Of course I wrote a business plan for it..duh..Thank You for your article encouraging me to do the same for my MillCityCrochet business on Etsy! *lightbulb;) Thanks so much for 250+ Vector Art the links! I'm just about to launch and 8+ Records Release Form Template | Resume Language, this is on [] my to-do list. :) Thank you so much for Release Template | Resume Language offering an awesome free Business Plan guide! I just printed it and I can't wait to get started. So can your plan be to have no plan? Perhaps this is why I never get anything done. I should check this out - right after my nap. Thanks for the link!

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The poor solubility of drugs can reduce the bioavability of dosage forms. Recent approaches have included the administration of drug components with lipid vehicles such as oils, liposomes and Form Template | Resume self-emulsifying formulations [1, 2]. []. This system was not use commonly but know the days importance of lipid based drug delivery system is very height due to poor water solubility of drugs. For the improving bioavability we formulate a new drug delivery system called self emulsifying drug delivery system By example, the bioavailability of Tipranavir (TPV), a nonpeptidic protease inhibitor anti-HIV drug, was doubled when dosed to rats in 8+ Records Release Template Language a SEDDS formulation versus delivered as solid powder in Job Appointment Letter a hard filled capsule [3]. developed a self-emulsifying drug delivery system for Coenzyme Q10 using polyglycolyzed glycerides as emulsifiers with a resultant 150% increase in Template | Resume Language bioavailability.4 Numerous other examples exist in the literature demonstrating enhanced bioavalibility with self emulsifying drug delivery systems 5-6 but most focus on a single formulation or small.[2] set of formulations with little explanation of how this formulation was developed. Current SEDDS formulation development, consequently, in general occurs through resource-intensive trial and You Letter error. Some mechanistic studies have been conducted exploring a range of 8+ Records Language SEDDS formulations and a specific aspect of their function, most commonly ability to emulsify [7, 8]. . Improved quantitative understanding of how properties of a specific self emulsifying formulation interact with the biological environment to enable oral absorption could help optimize SEDDS formulations for enhancing bioavailability. Although a significant amount of literature exists from other fields concerning the function of emulsions [9-10], pharmaceutical formulations have not been broadly studied with respect to fundamental aspects of Resume + Cover emulsion function, with few studies statistically developing predictive models that relate emulsion properties with formulation parameters [11]. In particular, analysis and optimization of emulsion function across a broad range of formulation parameters via experimental design has not been widely explored. 8+ Records Language. One poorly understood aspect about SEDDS is the influence of different formulation components on the overall performance of these drug delivery systems in vivo.

Different types of / Organization oils with different characteristics and different surfactants combined at different ratios may influence the performance in Release Form | Resume Language vivo drastically. There is no guidance currently available for formulating a drug with specific properties with self. emulsifying drug delivery formulations.12 It is therefore necessary to investigate the influence of formulation components with a quantitative and statistically designed and analyzed manner. Job Appointment Letter | Sample. 3 Another knowledge in which there is a lack of understanding is the mechanism of Template how self emulsifying drug delivery systems work to enhance the overall bioavailability of Confidentiality Agreement a hydrophobic drug orally. Suggested mechanisms responsible of functioning of SEDDS in the GI tract environment includes the increased drug solubilization in the aqueous lumen phase due to alterations in | Resume Language the composition and character of colloidal environment in the GI tract fluid and increased drug absorption due to enhanced permeability permeability (e.g. widening of tight junctions, changes to cellular processing) and lymphatic transport [13-14-15]. Student Health / Organization. Important mechanisms that would influence drug solubilization in the lumen is the rate and extent of digestion of lipidic formulation components. Another one is the rate at 8+ Records, which the drug is released from oil droplets especially during the process of ‘degradation’ of the emulsified drug carriers by / Cv + Cover Letter Set 01 By the digestive enzymes in vivo. It is essential to investigate the rate of digestion of self emulsifying formulation lipids, rate of drug release, as well as the 8+ Records Release Form Template, rate and And Human Services extent of drug transport across intestinal monolayer incorporated with SEDDS in order to understand and predict formulation functioning in GI tract. Knowledge gained from these mechanistic understandings can be used as quantitative expressions which then can be incorporated into a pharmacokinetic model that will predict oral bioavailability of a drug administered with self emulsifying drug delivery systems. To define and understand challenges involved with oral delivery of hydrophobic drug compounds it is necessary to present a overview of current technologies.

16. Oral intake has been the most sought-after route of drug delivery by the patients as well as the 8+ Records Template, manufacturers for the treatment of Letter | Sample most pathological states. Despite tremendous strides made in novel non-oral drug delivery systems (DDS) till date, majority of the drug formulations available in the commercial world today are the oral ones.17 Nevertheless, oral delivery of over 8+ Records Form Template | Resume one-half of the Letter, drug compounds through gastrointestinal (GI) tract gets diminished owing to their high lipophilicity and Form Template | Resume Language consequently poor aqueous solubility. Oral bioavailability of Health And Human Chart such drugs, being primarily a function of their solubility and dissolution,[18-19] tends to exhibit inadequate magnitude with high intra- and inter-subject variability. Besides, oral bioavailability also depends upon a multitude of | Resume Language other drug factors such as stability in GI fluidsintestinal permeability, resistance to metabolism by cytochrome P450 family of enzymes present in – Sample gut enterocytes and Release Form Template | Resume Language liver hepatocytes, and – Sample interaction with efflux transporter systems like P-glycoprotein (P-gp).[20,21] explicitly illustrates the mechanisms of the physiological pathways through which the bioavailability of a drug from the conventional formulations tends to get impeded. Several formulation approaches have been employed to improve the oral bioavailability of diverse drugs.

Amongst these, oral lipid-based DDS have proved their immense potential in 8+ Records Form | Resume improving the Mutual Confidentiality, poor and inconsistent drug absorption of 8+ Records Release | Resume Language many poorly water-soluble drugs, especially following their administration after meals.22 These include various types of lipid suspensions, solutions and emulsions.23 With applications in specific domains, the lipidic formulations, thus, have carved a singnificant niche in oral drug delivery. Self-emulsifying drug delivery systems (SEDDS) are relatively newer lipid-based technological innovations with immense promise in oral bioavailability enhancement of drugs. These formulations have shown to reduce the slow and incomplete dissolution of a drug, facilitate the 250+ Business Card Art, formation of its solubilized phase, increase the 8+ Records Release Template, extent of its transportation via intestinal lymphatic system, and 250+ Business Template | Download Art bypass the P-gp efflux, thereby augmenting drug absorption from the GI tract.24. Self emulsion having grate capacity yo increase the bioavability of poorly water soluble drugs. It’s a isotropic mixture of oil ,surfactant, this system oil globules bind with drugs and increase the solubility of drugs. SEDDS is also known as microemulsion system. It will increase bioavability of drugs 50-100% .25-26. 1. Solid self emulsifying drug delivery system (SSEDDS) 2. Liquid self emulsifying drug delivery system (LSEDDS)

Recently day by Form day a new drug molequle was found but the only problems is that the bioavability of the drugs. Because oral route is the most preferable route for the administration of drugs but poorly water soluble drugs having problems to formulates solid dosage form because it will reduce the bioavability of drugs.26. In the solid dosage forms numbers of excipients are use for the increasing drug solubility. Resume / Cv Set 01 By They can be help in enhancing the solubility of drugs. In the SEDDS we number of excipients are use. 3. Co- surfactants. 4. Solidifying agent. They all the excipients help in Form Template | Resume Language the inhancing the bioavability of drugs.26. SEDDS is the isotropic mixture of oil, surfactant and co-surfactant. / Cv + Cover Set 01 By Thy having the capacity to 8+ Records Template rapidely dissolve in stomach and instinal fluid and cover large surface area. due to this nature of SEDDS it will also use in the sustain relese drug delivery system for Resume + Cover Letter Set 01 the instant delivery of drugs. This system can be use to increase the 8+ Records Release Template | Resume, solubility of Thank You Letter drugs by the help of excipient’s in the oral dosage forms we can use PH modifier, water soluble organic solvents, surfactant, co-surfactants.

And oils are use long chain triglicryde and Release Form | Resume Language medium chain tryglyceried we also use PEG 400, propylene glycol, glycerin, non-ionic surfactants as water soluble organic solvents.36,37. 1.1 Composition of SEDDSs:- ‘ The nature of the oil’surfactant pair. ‘ The surfactant concentration. ‘ The temperature at which self-emulsification occurs. 1.1.1 Oils:- Oils can solubilize the lipophilic drug in – Sample a specific amount. It is the most important excipient because it can facilitate self-emulsification and increase the 8+ Records Release Form Template Language, fraction of lipophilic drug transported via the intestinal lymphatic system, thereby increasing absorption from the GI tract . Long-chain triglyceride and medium-chain triglyceride oils with different degrees of saturation have been used in the design of SEDDSs. Modified or hydrolyzed vegetable oils have contributed widely to the success of Manager [] SEDDSs owing to their formulation and physiological advantages. Novel semisynthetic medium-chain triglyceride oils have surfactant properties and are widely replacing the regular medium- chain triglyceride. 1.1.2 Surfactant:- Nonionic surfactants with high hydrophilic’lipophilic balance (HLB) values are used in formulation of SEDDSs (e.g., Tween, Labrasol, Labrafac CM 10, Cremophore, etc.). Form | Resume. The usual surfactant strength ranges between 30’60% w/w of the formulation in order to form a stable SEDDS.

Surfactants have a high HLB and hydrophilicity, which assists the immediate formation of o/w droplets and/or rapid spreading of the Card Template Free, formulation in the aqueous media. Release | Resume Language. Surfactants are amphiphilic in nature and Student / Organization they can dissolve or solubilize relatively high amounts of hydrophobic drug compounds. This can prevent precipitation of the 8+ Records Release Template Language, drug within the GI lumen and for prolonged existence of drug molecules. 1.1.3 Cosolvents:- Cosolvents like diehylene glycol monoethyle ether (transcutol), propylene glycol, polyethylene glycol, polyoxyethylene, propylene carbonate, tetrahydrofurfuryl alcohol polyethylene glycol ether (Glycofurol), etc., may help to dissolve large amounts of hydrophilic surfactants or the hydrophobic drug in Health / Organization Chart the lipid base. Release Form Template | Resume Language. These solvents sometimes play the role of the cosurfactant in the microemulsion systems.27.

1.2 Microemulsions or Self-Emulsifying Drug Delivery Systems (SEDDS) Emulsions in Resume / Cv general are thermodynamically unstable systems. The droplets of the dispersed phase are large. Microemulsions on Release Template Language the other hand are emulsion systems that have a droplet size of a few to 250+ Business Template Vectors | Download Free Vector hundreds of nanometers and are typical complex fluids that consist of three essential components: two immiscible fluids and 8+ Records Release Form | Resume a surfactant. Typically these are water-in-oil or oil-in-water microemulsions where the rheological properties of these two liquids and microstructure of the surfactant strongly affect the Thank, resulting microemulsion . Microemulsions and micellar solutions are distinguished from emulsions by the fact that the 8+ Records Form Template Language, average drop size does not grow with time, which is a manifestation of thermodynamic unstability. Micellar solutions and Business Card Template Art microemulsions on the other hand are assumed to be thermodynamically stable. Reasons why there is tremendous attention on SEDDS include industrial trend towards the discovery and development on hydrophobic drugs and the resolution of technology transfer, stability and regulatory issues by SEDDS and the fact that they have proven pharmaceutical benefit with commercially available compounds of up to 5 fold increase in bioavailability (cyclosporine, lipid soluble vitamins, HIV protease inhibitors etc.) Self-emulsifying drug delivery systems by definition are mixtures of an oil, one or more surfactants and optionally a co-solvent or co-surfactant which when introduced into 8+ Records Release Form Template | Resume Language an aqueous media, under gentle agitation, forms fine oil-in-water emulsions. These systems when incorporated with a drug compound, drug is distributed in Thank You Letter the aqueous solution entrapped inside oil droplets. SEDDS enable distribution of Release Form | Resume Language hydrophobic drug component in the aqueous media and creates a drug solubilization in the gastrointestinal environment. Distribution of Business Card Template Vector Art drug inside oil droplets prevents drug from being an Form | Resume, undisolved substance, precipitating and being excreted from body.

However their mechanisms of action in the body are not limited to solubilization enhancement and also include other processes such as intestinal permeability and lymphatic transport enhancement. SEDDS by nature are thermodynamically stable emulsions compared to unstable regular emulsions. Their stability is Thank, thought to be dependent on their relatively small dispersed oil droplet size and narrow range of droplet distribution. SEDDS are typically composed of emulsion droplets having a diameter of 8+ Records Form Template | Resume 50 nanometers to 500 nm whereas systems having droplet size less than 50 nm are called self nano emulsifying drug delivery systems (SNEDDS). For a given drug only very specific formulations will give efficient emulsification and | Sample a self-emulsifying system that will work to enhance bioavailability. Efficiency of SEDDS therefore, as explained in detail by Gursoy et al., is governed by Template | Resume surfactant concentration, oil/surfactant ratio, polarity of the Manager Resumes [], emulsion, droplet size and charge of the droplets. However, the mechanism that governs self-emulsification has not yet fully understood. It is suggested that water penetrates through the 8+ Records Template | Resume, gel and Student Health And Human / Organization LC phases that occur at the surface of the droplets. This is followed by the solubilization of the water in Release oil phase until the solubilization limit is reached. After the | Sample Templates, limit is reached, formation of dispersion of LC phase is formed and this depends on the surfactant concentration. 8+ Records Language. Wit this formation, SEDDS become resistant to coalescence.

Emulsion stability is governed by a variety of factors such as physical nature of the interfacial film, presence of Resume + Cover Set 01 electrostatic or steric barriers on 8+ Records Template | Resume Language the droplet, viscosity of the continuous phase, droplet size distribution, oil to water ratio, temperature and the amount of surfactant that is absorbed on Resume / Cv the surface of the oil droplet. The more surfactant is absorbed on the surface, the more decreased the interfacial tension between oil and water which consequently yields delayed coalescence of droplets by electrostatic and steric repulsio. Although with the Release Form Template | Resume, addition of high amounts of drug, which is common case for potential oral dosage forms, it is Student Health And Human Chart, harder to have stabilized emulsions. In this case, the need of using more surfactant arises that have negative aspects such as increased toxic effect of the formulation. 1.3 ADVANTAGES OF SEDDS :- ‘ More consistent drug absorption, ‘ Control of delivery profile. ‘ Reduced variability including food effects.

‘ Enhanced oral bioavailability enabling reduction in dose. ‘ High drug loading efficiency. ‘ For both liquid and solid dosage forms. ‘ These dosage forms reduce the gastric irritation produced by drugs.25-26. 1.4 APLLICATION OF SEDDS : Main application of this SEDDS to increase the bioavability by 8+ Records Form | Resume Language increasing the solubility of drugs. In this system we use oils for the increasing the solubility of drugs . the oils can form a layer of globules on [] the drug so it will easily dissolve in the water.27.

1.5 Solubility and Release Form Template | Resume Process of Solubilization. In bioavailability of Resumes [] drug, solubility plays a key role because it is vital determinant of Release drug release and absorption. Any drug showed pharmacological response when it achieves desired concentration in systemic circulation and – Sample it is depending upon 8+ Records Template | Resume solubility. Solubility is the maximum amount of solute dissolved in a certain amount of solvent at a specified temperature. (Shinde A. J., 2007) 1.5.1 Process of And Human Services / Organization solubilization. Factors affecting solubility.

1. Particle size. 4. Other: Nature of the solute solvent, Molecular size, Polarity, Polymorphs. Absolute bioavailability and Relative bioavailability. Absolute bioavailability Intravenous dose is selected as a standard because the drug is administered directly into the systemic circulation (100% bioavailability) and avoids absorption step. Intramuscular dose can also be taken as a standard if the drug is poorly water soluble. An oral solution as reference standard has also been used in certain cases, but there are several drawbacks of using oral solution as a standard instead of an i.v. dose. Relative or comparative bioavailability. It is also termed as comparative bioavailability. It is denoted by Fr.

In contrast to Release Form Template absolute bioavailability; it is used to characterize absorption of a drug. Methods for enhancement of bioavailability. As per definition of bioavailability, poor permeability through the biomembrane owing to | Sample inadequate partition coefficient or lipophilicity or large molecular size such as that of protein or peptide drugs are poor bioavailable drugs. Both poor solubility and permeability of drug is depends upon its physicochemical property. Biopharmaceutical Classification System (BCS) Based on intestinal permeability and solubility of drugs, Amidon et al., developed Biopharmaceutical Classification System (BCS) which classify drugs into one of the four groups. Class I: These are well absorbed orally since they have neither solubility nor permeability limitation. Class II: Shows variable absorption owing to 8+ Records Release Form Language solubility limitation. Class III: also shows variable absorption owing to permeability limitation. Class IV: are poorly absorbed orally owing to | Sample Templates both solubility and permeability limitation. There are three approaches in overcoming bioavailability problems are: It includes alteration of formulation, manufacturing process or physicochemical properties of Release Form Template | Resume drug devoid of changing chemical structure.

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10. 8+ Records Template | Resume Language. Use of amorphous, anhydrates, solvates and metastable polymorphs. 11. Solvent deposition. 13. Selective adsorption on insoluble carriers. 14. Agreement – Sample. Solid solution. 15. Eutectic mixture. 16.

Solid dispersion. 17. Molecular encapsulation with cyclodextrin. By enhancing drug permeability across biomembrane. 1. Lipid technology. 3. Penetration enhancers. By enhancing drug stability. 1. Enteric coating. 3. Use of metabolism inhibitors. 1.5.3 Problems and Breakthroughs of Bioavailability Enhancement Techniques. When poor wetting properties and difficulties in processing of powders are problems reduction in particle size can not applicable in such conditions. So as to avoid such problems many other techniques have been used such as solid dispersions, permeation enhancers, cyclodextrins and nanoparticles. In fact, in some special cases, such approaches have been doing well.In the technique of reducing the size of particles, there is affinity for agglomeration of Release particles due to high surface charges on small discrete particles. 1.5.4 Lipid based drug delivery. Ideal properties of Lipid based formulations. 1. It should solubilize therapeutic amounts of the drug in the dosage form. 2. It should maintain adequate drug solubility over the entire shelf-life of the drug product (generally 2 years) under all anticipated storage conditions.

3. It should provide adequate chemical and physical stability for the drug and Thank formulation components. 4. It must be composed of approved excipients in safe amounts. 5. It should adapt to the digestive processes of the GI tract such that digestion either enhances or maintains drug solubilization. 6. It should present the 8+ Records Release Form Language, drug to the intestinal mucosal cells such that absorption into the cells and into the systemic circulation is optimized. 2.0 NEED FOR STUDY OBJECTIVE. Oral route is the most convenient and preferable route for the administration of drugs but the Job Appointment Templates, problems is 8+ Records Release Form, occurs due to the low solubility of Job Appointment Templates drugs. About 50% of recently find drug molecules can not be formulate in the solid dosage form because of there low solubility. The need of 8+ Records Release Template | Resume Language this study was to increase the solubility of poorly soluble compound. In this formulation we can formulate a self emulsifying drug delivery system with the active ingredient telmisartain. Telmisartain practically water insoluble drugs. And having poor bioavability by the help of LSEDDS we can increase solubility of telmisartain.

3. LITRATURE SURVEY. 1. . Saritha,D. et al. (2014) Prapration a stable formulation for self emulsifying drug delivery systems (SEDDS) in order to enhance the Student And Human Services / Organization Chart, solubility, release rate, and oral absorption of the 8+ Records Template, poorly soluble drug, indomethacin. Based on the solubility of indomethacin in / Cv + Cover By oil, surfactant and cosurfactant, pseudo-ternary phase diagrams were developed in 1:1, 1:2, 2:1, 1:3, 3:1, 4:1 ratio for SEDDS composed of labrafil, cremophor EL and transcutol P. 8+ Records Release Template | Resume Language. Formulations were evaluated for drug content, phase separation, turbidimetry, zeta potential, globule size, refractive index and in Resume / Cv + Cover Letter Set 01 vitro release. The study illustrated the potential of indomethacin SEDDS for oral administration and its biopharmaceutic performance.33. 2. Damineni,S et al (2014) developed self emulsifying drug delivery system of ibuprofen to enhance solubility, dissolution rate which may improve therapeutic performance and Template | Resume drug loading capacity so as to 250+ Vectors Vector develop alternative to traditional oral formulations to improve bioavailability. Language. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively.

Formulation development and screening was done based on results obtained from phase diagrams and characteristics of 250+ Business Template Vectors Vector resultant microemulsions. The developed SEDDS were evaluated for droplet size analysis, zeta potential, polydispersibility index, viscosity, refractive index, % transmittance, drug content and in vitro diffusion profiles.34. 3. Kumar,S. et al (2014) in this article we have study upper surface of SEDDS. The main advanced topic in this article is solidification process of 8+ Records Template | Resume Language LSEDDS and the development of solid SE dosage the 250+ | Download Free Vector, last find he prolems of the system and solve it.35. 4. Reddy,M. 8+ Records Release. et al (2014) In this article we have conclude, today huge numbers of formulation avalables for the increasing poor water solubility of 250+ Business Card Template Vectors Free Art drugs , dissolution rate and bioavailability of Release Form Template insoluble drugs. One of the promising techniques is Self’Micro Emulsifying Drug Delivery Systems (SMEDDS).

Liquid SEDDS were prepared using LLWL 1349, Labrafac PG as oils and Job Appointment | Sample Templates cremophor EL, cremophor RH40 as surfactants and 8+ Records Release Form Template | Resume labrasol, transcutol HP as co-surfactants. Prepared liquid SEDDS were evaluated for stability, particle size, zeta potential and percent transmittance. Manager. Selected liquid formulations were converted to 8+ Records Form Template | Resume Language solid SEDDS by adsorbing onto a solid carrier Neusilin. Prepared solid SEDDS were evaluated for 250+ Card Template Free Art flow properties and 8+ Records Form in-vitro drug release studies. Results proved that prepared solid SEDDS have good flow properties and improved drug solubility and dissolution profiles (99.95%) when compared to pure efavirenz.36.

5. Confidentiality Agreement – Sample. Amrutkar,C. et al (2014) The aim of the present study is to 8+ Records Form Template | Resume improve solubility and hence bioavailability of Rosuvastatin calcium using self nanoemulsifying drug delivery system (SNEDDS). self emulsifying property of various oils was evaluated with suitable surfactant and co-surfactants. Mutual Agreement. Ternary phase diagram was constructed based on Rosuvastatin calcium solubility analysis for optimizing the systems. The prepared formulation were evaluated for self emulsification time, dispersibility study, average globule size, Polydispersibility index (PDI). The globule size of optimized system was less than 100nm which could be an acceptable nanoemulsion range. The average globule size of the Release Template | Resume, selected F2 SNEDDS formulation (Capmul MCM [20%], Tween 20 [40%] and PEG 200 [40%]) was 88.01nm. In vitro drug release studies showed remarkable increase in dissolution of 250+ Card Template | Download Free F2 SNEDDS compared to Release | Resume marketed formulation.37. 6. . Choudhary,S.B. et al (2014) revealed formulated and characterization solid self emulsifying drug delivery system (SSEDDS) of domperidone for filling into soft gelatine capsule.

Pseudo ternary phase diagrams were constructed and Services / Organization liquid SEDDS formulations were prepared which consists of oleic acid, tween 20 and propylene glycol as oil phase, surfactant and cosolvent respectively. 8+ Records Form. The self emulsification properties, globule size, polydispersity index of liquid SEDDS formulations were studied upon dilution with water. The solid SEDDS was prepared by spray drying method and kneading method using Aerosil 200 as solid career. Agreement. The solid state characterization of the solid SEDDS was performed by SEM, DSC, and X-ray powder diffraction. The results from this study demonstrate the potential use of SEDDS as a means of Form Template Language improving solubility, dissolution, and concomitantly the bioavailability.38. 7. .Gikwad,S. et al. (2012) A reaserch on 250+ Template self-emulsifying drug delivery system (SEDDS) to enhance the solubility of the poorly water-soluble drug Orlistat. These drugs can be successfully formulated for oral administration, but care needs to be taken with formulation design to ensure consistent bioavailability.

Solubility of Orlistat was evaluated in various nonaqueous carriers that included oils, surfactants, and cosurfactants. Pseudoternary phase diagrams were constructed to 8+ Records Release identify the self-microemulsification region. The self microemulsification properties, droplet size and thermodynamic stability of these formulations were studied upon dilution with water.38. 8. . Thank. Sachan,R. et al. (2010) To develop a formulation For the improvement of | Resume Language bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to Job Appointment Letter | Sample traditional oral formulations to improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively. Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions.39. 9. Liu Y., et al., (2009) optimized and characterized an oridonin SMEDDS formulation using central composite design. In this study effect of concentration of oil andsurfactant and 8+ Records | Resume co-surfactant ratio has been studied. Study concluded that, this model is Manager [], useful for optimization of SMEDDS formulation. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.40. 10.

Balakrishnan P., et al., (2009) prepared a solid SMEDDS of dexibuprofen by spray drying technique using Aerosil 200 as a solid carrier. After conversion in to 8+ Records Template solid form S-SMEDDS retains its self emulsification capacity. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation. Resumes []. In-vivo study showed that increase in bioavailability. Study concluded that, in the form of Solid SMEDDS it retains all characteristics of liquid and it can become helpful solid dosage form.41. 11. Singh A. K., et al., (2009) prepared and evaluated SMEDDS of Exemestane using Capryol 90, Cremophore ELP, and Transcutol P. They compared drug release with marketed formulation in different pH. They found extensive increase of drug release than marketed formulation. They also compared absorption of drug with that of drug suspension. Form | Resume Language. They found enhanced drug absorption from 250+ Business Template Free Vector, SMEDDS.

Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of Release Template Language poorly water soluble drug.42. 12. Shaji J., et al., (2008) formulated and evaluated SMEDDS of Mutual Agreement Celecoxib. 8+ Records Release | Resume Language. They optimized formulation using 33 factorial design. Particle size was taken as response variable. Study showed that, concentration of different components showed prominent effect on particle size and appearance of dispersion. They found enhanced drug absorption from SMEDDS. Thank. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.43.

13. Atef E., et al., (2008) formulated and Template | Resume Language evaluated SMEDDS of Health Services / Organization phenytoin and Template Language compared its relative bioavailability with marketed formulation. Results showed that, extensive increase in drug release form SMEDDS as compared to that of marketed suspension. Also in-vivo study showed improvement in bioavailability. Study concluded that, SMEDDS is promising formulation to increase drug release as well as bioavailability of poorly water soluble compounds In-vitro drug release showed that, there was increase in drug release as compared to 250+ Vectors powder formulation.44. 14. Fatouros D. G., et al., (2008) studied dynamic lipolysis model for absorption of drug from SMEDDS formulations. They also studied IVIVC with the help of 8+ Records Release Language neuro-fuzzy networks.

Study concluded that, in evaluation of SMEDDS for prediction of in-vivo behavior in-vitro dynamic lipolysis model is Student Health Services Chart, a possible means.45. 15. Shikov A., et al., (2008) Prepared and Template | Resume characterized SMEDDS of flavonoids. Prepared SMEDDS formulation was evaluated for self emulsification capacity, droplet size and for bioavailability. Results showed that, They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug. there was 2-5 fold increase in Thank bioavailability as compared to flavonoid in powder form.46. 16.

Woo J. S., et al., (2008) developed SMEDDS of Itraconazole and studied and compared in-vivo study in human volunteers with marketed formulation having double dose. Release Form | Resume. Study concluded that, there is extensive increase in bioavailability with reduced food effect by Manager Resumes SMEDDS formulation as compared with marketed formulation. They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and 8+ Records Template Language hence bioavailability of poorly water soluble drug.47. 17. Mandawgade S. D., et al., (2008) developed SMEDDS using natural lipophile as oil phase and also compared its performance with synthetic oils. Health. For this study beta-Artemether was used as drug.

Oil was previously evaluated for toxicity studies. Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. 8+ Records | Resume Language. Study concluded that, performance of Chart natural lipophiles is 8+ Records, better than that of commercially available synthetic oils hence can be used in Job Appointment Letter | Sample SMEDDS as it is Language, safe.48. 18. Yi T., et al., (2008) developed a controlled release solid SMEDDS of nimodipine using HPMC. They have prepared batches by mixing drug with HPMC and Letter Templates another batch by dissolving drug and HPMC in the SMEDDS. Prepared self emulsifying formulations were evaluated for surface characterization, reconstituted properties, inner physical structure and in-vitro drug release study. Study concluded that, It can be possible to formulate controlled release formulations of poorly water soluble drug by | Resume SMEDDS using high viscosity grade HPMC.49. 19.

Yi T., et al., (2008) developed a S-SMEDDS of nimodipine. Prepared S-SMEDDS was evaluated for in-vitro and in-vivo absorption study. []. They have studied effect of 8+ Records Form | Resume dilution media and enzymatic digestion on solubilization of drug .Results showed that, there is faster dissolution rate of drug from Thank You Letter, S-SMEDDS than that of conventional tablet and enhancement of absorption as compared to liquid SMEDDS. . 8+ Records | Resume Language. Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. Resumes. Study concluded that, performance of 8+ Records | Resume Language natural lipophiles is better than that of commercially available synthetic oils hence can be used in SMEDDS as it is safe. Study concluded that, S-SMEDDS can become constructive dosage form for oral use.50. 20. Abdalla A., et al., (2008) Study concluded that, S-SMEDDS can become constructive dosage form for oral use. developed self emulsifying formulation in the form of pellets by extrusion and spheronization technique. In. this study they found that, droplet size decreases after dilution. Study concluded that, solubilzation depend on concentration of secretions like bile salts and phospolipid.

SMEDDS can besuccessfully transformed into Job Appointment Letter | Sample pellets form and 8+ Records Release can become another method to encapsulate material into hard gelatin capsule.51. 21. Lu J. L., et al., (2008) developed SMEDDS of 9NC to enhance bioavailability and anticancer effect. They prepared microemulsion of 9NC and characterized for citotoxicity and bioavailability study. Letter | Sample Templates. Bioavailablity and anticancer effect have been compared with suspension of 9NC. Study concluded that, antitumor activity has been enhanced in the form of SMEDDS.52. 22. Patel D., et al., (2007) developed SMEDDS of 8+ Records Release | Resume Acyclovir. Prepared formulations were evaluated for 250+ Business Card | Download different parameters.

Absorption of drug from SMEDDS was compared with plain drug solution. Results showed that, there was 3.5 fold increases in bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach. 8+ Records Release Template | Resume Language. . You Letter. Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in Release Form Template Language plasma triglycerides when compared with reference formulation of drug suspension. Study concluded that, there was better biopharmaceutical performance of drug from SEDDS.53. 23.

Cirri M., et al., (2007), formulated oral liquid spray formulation of Health And Human Chart xibornol using SMEDDS. Prepared formulations were evaluated for rheological, stability, SAXS and Release Template | Resume in-vivo study. The study found that, SMEDDS can be used to prepare stable and effective oral liquid spray formulation. Absorption of drug from SMEDDS was compared with plain drug solution. Results showed that, there was 3.5 fold increases in bioavailability by Health And Human Services Chart SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach.54.

24. Patil P., et al., (2007) formulated a SEDDS for simvastatin. Prepared SEDDS was evaluated for turbidometric analysis, particle size, in-vitro drug diffusion and in-vivo study in Form rat. Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of drug suspension. You Letter. Study concluded that, there was better biopharmaceutical performance of Release Language drug from SEDDS.55. 25. Patel A. R., et al., (2007) formulated and evaluated SMEDDS of fenofibrate. Resumes. From solubility study of drug in different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. 8+ Records Form | Resume Language. From this SMEDDS were prepared and evaluated for thermodynamic, dissolution, stability study and Thank lipid lowering capacity. 8+ Records Release Form Template. Study concluded that, SMEDDS can improve dissolution rate and hence bioavailability of drug which become substitute for oral drug delivery system. Study concluded that, there was better biopharmaceutical performance of drug from SEDDS.56.

26. Letter. Shen H., et al., (2006) prepared and evaluated SMEDDS of atorvastatin using Labrafil, PEG and Cremophor RH40. From solubility study of drug in different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. SMEDDS capsule of atorvastatin were prepared and drug release were studied and compared with conventional tablet. 8+ Records Template Language. Results showed that release of Mutual Agreement – Sample drug was much higher from SMEDDS capsule than that of tablet. Study concluded that, bioavailability of drug can be enhanced using SMEDDS capsule than conventional tablet. controlled release of drug can be obtained from lipid formulations in tablet dosage form.57.

27. Boonme P., et al., (2006) characterized colloidal state in microemulsion system. They constructed pseudo ternary phase diagram by water titration method. different process parameters affect dissolution rate of drug from tablet. Study concluded that, controlled release of drug can be obtained from 8+ Records Release Language, lipid formulations in tablet dosage form. Different samples were prepared by Manager Resumes [] keeping surfactant concentration of 45 % and by varying proportion of water.

Prepared samples were evaluated for appearance, viscosity, conductivity, DSC, SEM and NMR. Study concluded that, if composition has 15 % of water, it contain reverse micelles, W/O emulsion obtain if it contain 15-30 % of water and it gives O/W emulsion of it contain more than 35 % of water.58 28. 8+ Records Form. Nazzal S., et al., (2006) evaluated different process parameters which affect release of drug from SNEDDS in tablet dosage form. Solid preparation was prepared to study absorption of drug in rat and dog. You Letter. Prepared tablets were evaluated for dissolution and Release Form | Resume Language stability studies. Results showed that, different process parameters affect dissolution rate of drug from Resumes [], tablet. Study concluded that, controlled release of drug can be obtained from lipid formulations in 8+ Records Form Language tablet dosage form.59 29.

Wu W., et al., (2006) prepared SMEDDS of silymarin. From solubility study of drug Tween 80, ethyl alcohol and ethyl linoleate were selected as formulation components Solid preparation was prepared to Thank You Letter study absorption of drug in Form Template | Resume rat and dog. Results showedthat Florite RE gives more absorption of drug both in rat and dog. Results showed that, there is increase in particle size as increase in Mutual – Sample drug loading in 8+ Records Release Template formulation. Drug release was much higher than that of crude drug powder. Study concluded that by using SMEDDS bioavailability of | Sample silymarin can be enhanced.60 30.

Ito Y., et al., (2005) prepared solid formulation of gentamicin using different adsorbents and surfactant to enhance absorption of drug. Florite RE, Neusilin US2 and Sylysia 320 were used as adsorbents and Form | Resume Language Labrasol was used as surfactant. Prepared formulation was evaluated for particle size, drug release and bioavailability study. 250+ Business | Download Art. Results showed that, there is increase in particle size as increase in drug loading in formulation Study concluded that by using adsorbent and 8+ Records Release Template | Resume Language surfactant system oral solid formulations can be prepared so as to increase absorption of poorly absorbable drug.61 31. Sha X., et al., (2005) studied effect of charge and dilution on TEER and permeability of mannitol by formulating SMEDDS using Labrasol and also studied effect of 250+ Template Vectors | Download Vector Art dilution of surfactant on ZO-1 and F-actin. Study concluded that, SMEDDS of both positive and negative charge containing Labrasol are capable of enhancing the paracellular tramsport of mannitol across Caco-2 cell at different dilutions. , there was significant increase in rate and extent of absorption of drug as compared to Form | Resume capsule. It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for Resume / Cv + Cover Letter By oral delivery of poorly water soluble drug such as simvastatin.62 32. . Subramanian N., et al., (2004) developed and optimized SMEDDS of Celecoxib using simplex lattice mixture design. Release Form Template | Resume Language. Prepared SMEDDS were evaluated for Clarity, solubility, in-vitro dissolution and in-vivo study. Results showed thatRelative bioavailability with capsule was found to be 132 %. Study concluded that, prepared formulation will reduce variability in absorption and rate and gives rapid onset of action of drug.

It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of poorly water soluble drug such as simvastatin.63 33. Kang B. K., et al., (2004) prepared SMEDDS of simvastatin using Carpryol 90, Cremophor EL and Manager [] Carbitol. Prepared formulations were evaluated for Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug, in-vitro dissolution study and bioavailability study. Results showed that, in-vitro of drug was much higher that that of conventional tablet. It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of poorly water soluble drug such as simvastatin.64 34. Patil P., et al., (2004) formulated a gelled SEDDS of ketoprofen using Captex 200, Tween 80 and Capmul MCM.

Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug. Study concluded that, as concentration of gelling agent increases it increase droplet size of Release Form Template | Resume emulsion formed which helps in And Human Chart slowing drug diffusion. It was also found that, as concentration of co-surfactant increase drug release from 8+ Records Form Template Language, dosage form also increases.65 35. Holm R., et al., (2003) importance of this examined oral absorption and 250+ Business | Download lymphatic transport of 8+ Records Form Template halofantrine in SMEDDS containing triglycerides, Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug. Maisine-35-1 and Cremophor EL. Study verified that, after administration of halofantrine in SMEDDS lymphatic transport and absorption was affected. Study concluded that, by using differentstructure of triglycerides it is Manager, achievable to enhance lymphatic transport of compound without affecting its availability.66 36. Itoh K., et al., (2002) the aim of this present researched topic improved solubility of N-4472 by formulating self-micro emulsifying system using Gelucirei??i?? 44/14, HCO and SDS. Study concluded that, formulate sedds to Release Form Language enhance the bioavability and formed stable microemulsion droplets. SDS showed vital role in stability of microemulsion droplets.67 37.

Agarwal V., et al., (2000) investigated effect griseofulvin SMEDDS addition to Manager Resumes silica and silicate on flow properties and in-vitro drug release. 8+ Records | Resume Language. Results showed that, increase in And Human surface area increases dissolution of drug. Study concluded that, nature and amount of 8+ Records Release Form Template | Resume Language adsorbent affect flow properties and dissolution of drug in SMEDDS. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.68 38. Kim H. J., et al., (2000) developed SMEDDS of You Letter idebenone using Labrafil 2609, Labrasol. 8+ Records. Transcutol and / Cv + Cover Letter Set 01 By Plurol oleique WL1173 so as to enhance bioavailability by the increasing the solubility of the poorly water solublr drug. Release Template. Results showed that, in-vitro dissolution rate of drug were increased 2 folds than that of tablet. Study concluded that, SMEDDS can be used as substitute for traditional oral formulations to enhance bioavailability of idebenone.69 39. Chen G. L., et al., (1996) the importance of this present researched study was validated bioanalytical method for determination of Verapamil from plasma by HPLC for pharmacokinetic study of Verapamil. They also studied sensitivity, specificity, linearity, accuracy, precision and sample stability of method. For the purpose of + Cover sedds evaluation.70 40.

Shah N. H., et al., (1994) the aim of this study was investigated emulsification efficiency of 8+ Records Release Form Template Language polyglycolyzed glycerides (PGG) and polyethylene glycol (PEG). They prepared SEDDS using different concentrations of PGG as emulsifiers,oils and different type of surfactant and co-surfactant. Neobee M5 and Peanut Oil were selected as oil. Drug having good solubility in oil was selected for this study. Study showed that, PGG can be used as emulsifier for preparation of Job Appointment SEDDS.71 MATERIAL METHOD 4. MATERIAL AND METHOD 4.1 MATERIALS Table 4.1: List of materials with sources S. No. Materials Source 1. Telmisartan Skymap Pharmaceuticals, Roorie 2. Tween 80 Loba chemic laboratory regents Mumbai 3. PEG 400 Nasco laboratory 4. Methanol Loba chemic laboratory regents Mumbai 5. Hydrochloric acid Loba chemic laboratory regents Mumbai 6. Orange oil Burgone laboratory Mumbai Table 4.2: List of equipments with make S. No. Equipment Make 1. Analytical balance Fuji electronic balance 2. Melting point apparatus Jyoti digital auto melting apparatus 3. Form Language. UV – Spectrophotometer Jasco japan-v630 4. / Cv Letter By Dissolution apparatus Jyoti standard dissolution apparatus 5. FTIR Jasco-japan FT/IR/4100 7. mixing Jyoti lab gwl. INDIA 8. Hot air oven Jyoti lab gwl.

INDIA 9. Water bath Jyoti lab gwl.INDIA 4.1.1 Drug profile: Telmisartan72 Telmisartan is 4’-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Structural formula ‘ Figure 3.1: Structure of telmisartan Molecular formula- C33H30N4O2 Molecular weight- 514.6 Definition 4’-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Content: 99.0 per cent to 8+ Records Form 101.0 per cent (dried substance). Category: Antihypertensive. Dose: 20 to 80 mg. Half life: 24 hrs. Appearance: White or slightly yellowish, crystalline powder. Solubility: Practically insoluble in Card Template | Download Free water, slightly soluble in methanol, sparingly soluble in Release Form Template methylene chloride.

It dissolves in 1 M sodium hydroxide. It exhibits polymorphism. Melting point: 261 ‘ 263oC. Storage: it should be stored at room temperature (15 – 30 i??i??C), away from moisture and light. Resume / Cv + Cover Letter By Mechanism of action: It is an angiotensin II receptor antagonist. Telmisartan exhibits high affinity with the angiotensin II type one receptors in adrenal gland and in Release Template | Resume vascular smooth muscles. 250+ Business | Download. It works by binding to the angiotensin II receptor. It inhibits the action of angiotensin which is a vasoconstrictor.

Angiotensin also stimulates the synthesis and | Resume Language release of aldosterone. By blocking the Resume / Cv Set 01, vasoconstrictor effect of the Form Template, angiotensin and blocking the aldosterone, Telmisartan reduces the systemic vascular resistance. Pharmacokinetics: Absorption: After the oral administration peak concentrations (Cmax) of telmisartan are attained in 0.5 to 1 hour. Resume / Cv + Cover By Ingestion with food slightly decreases the bioavailability of Telmisartan. Absolute bioavailability is Release | Resume Language, dose dependent. At 40 and 160 mg the bioavailability was found to be 42% and 58%, respectively. Distribution: Binding with plasma proteins is And Human Chart, constant with the recommend doses. It is Form Template | Resume Language, highly binding with the Card Vectors | Download Free Art, plasma proteins (more than 99.5 %).

It has a volume of distribution of around 500 L. Metabolism: Telmisartan is metabolized by 8+ Records Release Template forming a pharmacologically inactive compound acyl glucuronide by conjugation. The only + Cover, identifiable compound in the human plasma and Form Language urine is the Resume Set 01, glucuronide. Elimination: Telmisartan has a half life of 24 hour and total plasma clearance of more than 800 mL/min. More than 97% of the orally/IV administered telmisartan is eliminated in the feces via biliary excretion, unchanged. Uses: It is used to treat high blood pressure (hypertension). Adverse effects: The common reported adverse effects of telmisartan are upper respiratory tract infection (URTI) (7%), Back pain (3%), Diarrhea (3%), Myalgia (3%), and Sinusitis (3%).

Some rare adverse effects (1%) are abnormal ECG, anemia, angina, angioedema, bradycardia, eczema, epistaxis, gout, and 8+ Records Release hypercholesterolemia. Drug interactions: Telmisartan has found interacting with several drugs such as, benazepril, benazepril, benazepril, benazepril, benazepril, and benazepril etc. Caution is advised when combination will be used. Health And Human. Dosage forms: It is Release Form Template | Resume, commonly used in the form of tablets of 20, 40, and 80 mg. 4.1.2 TWEEN 80 72-73 Chemical Name: Tween 80 Molecular Formula: C24H44O6 Formula Weight: 428.600006103516 Tween 80 Property Boiling point- 100i??i??C. Dencity – 1.08 g/mL at 20 i??i??C. Vapour pressure- 230 i??i??F. storage temp. Manager Resumes []. : Store at RT. From- viscous liquid. Water Solubility : 5-10 g/100 mL at 23 i??i??C. EPA Substance Registry System: Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.(9005-65-6)

Tween 80 Chemical Properties,Usage,Production. Yellow to amber liquid. Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste. Air Water Reactions.

Tween 80 is incompatible with strong alkalis and oxidizers. Tween 80 is probably combustible. 4.1.3 ORANGE OIL 72-73:- It was the 8+ Records Release Form Language, important and essincial oil can be produse by Mutual Confidentiality Agreement the cells in the fruits of oranges. They can also be extracted by orange juse it will compose mostely d-limonene. That will be extract to the oil by distillation. Odour- fresh and tangy smell, Coloue- yellow to orange in color. Self life- approximately 6 months.

Origin of Sweet orange oil. This evergreen tree has dark green leaves and white flowers and bright orange round fruit with roughish skin. Release Form Language. The trees are native to China, but are now cultivated extensively in America. 1. It can be used many Curacao type liqueurs. 2. for You Letter the flavoring of food. 3. drink and confectionery. 4. when added to furniture polish. 5. helps to protect against damage from insects. The orange oil are extracted by Form Template Language cold-pressing and yields 0.3 -0.5 %. It can also use for the medicinal perpose that will gives several therapeutic actions are antiseptic, anti-depressant, antispasmodic, anti-inflammatory, carminative, diuretic, cholagogue, sedative and tonic. The main chemical components of orange oil are a-pinene, sabinene, myrcene, limonene, linalool, citronellal, neral and geranial.

1. Resume / Cv. It is a safe non-toxic, non-irritant and 8+ Records Form Template | Resume Language non-sensitizing oil, 2. yet care must be taken with it since it can have a phototoxic effect. 3. It should therefore preferably not be applied before going out into sunlight for prolonged periods. Iupac name – polyethylene glycol. – 90.0 cst at Student Health And Human Services Chart, 25 i??i??C, 7.3 cst at 99 i??i??C.

PEG 400 properties. 1. Release Form Language. (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. 2. You Letter. It is a clear, 4. viscous liquid. 5. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations. 1. PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

2. PEG 400 is strongly hydrophilic. 3. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log ), indicating that when PEG 400 is mixed with water and hexane, 4. there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1] PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons. 4.2 Preformulation studies 72,73,74,75. To develop a safe, stable and 8+ Records Release Form Template therapeutically effective dosage form, preformulation studies are necessary to perform. The preformulation studies, which were performed in this project, include identification of drug, melting point analysis, solubility analysis, and quantitative estimation of drug.

4.2.1 Identification tests. ‘ Physical appearance: The drug was white, odorless crystalline powder. ‘ Melting point analysis: Melting point of telmisartan was determined by Job Appointment | Sample Templates capillary method using melting point apparatus (Rolex- Digital melting point apparatus). ‘ FTIR study: Drug sample was vacuum dried for 12 h before IR studies. Release Language. IR spectra of pure telmisartan, PEG 4000, mannitol and Services Chart solid dispersions of telmisartan were obtained by a Shimadzu IR Prestige-21 FT-IR spectrophotometer using KBr pellets. The scanning range used was 4000 to 400cm-1.

The observed peaks were reported for functional groups. 4.2.2 Loss on drying73-74. It was determined on 1 g drug by drying it in a hot air oven at 105oC. The weight was determined at 15 min intervals till the difference was not more than 0.5 mg. The total difference in weight should not be more than 0.5%. 4.2.3 Determination of ‘max 73. Accurately weighed sample of 8+ Records Release Template Language 10 mg of Health And Human Services telmisartan was dissolved in 50 mL of methanol in a 100 mL volumetric flask and then the volume was made up to 100 mL with methanol.

Then, 1 mL of this stock solution was pipetted into a 10 mL volumetric flask and volume was made up to the 10 mL mark with methanol. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). The same procedure was followed to determine the ‘max in HCl buffer (pH 1.2). The prepared solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu). To determine ‘max in water, accurately weighed 10 mg sample of telmisartan was dissolved in 50 mL of methanol in 8+ Records Release Language a 100 mL volumetric flask and volume was made up to 100 mL with methanol. Then, 1 mL of this stock solution was pipetted into a 10 mL volumetric flask and volume made up to Letter | Sample Templates the 10 mL mark with distilled water. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). 4.2.4 Quantitative estimation of drug73-74. Drug was estimated in the range of 3-15 mcg/mL for 8+ Records Template telmisartan in water (pH 7.0), HCl buffer (pH 1.2) and methanol.

Preparation of HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in Mutual Confidentiality Agreement – Sample a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and Template | Resume Language volume was adjusted to 200 mL with distilled water32. 4.2.5 Construction of Mutual – Sample calibration curve of telmisarta73. Preparation of calibration curve in methanol: The 25mg of accurately weighed telmisartan was dissolved in 25 mL of methanol to give standard solution (1000 i??i??g/mL). From this standard solution, 3 mL was pipetted out and 8+ Records Template volume was made up to 100 mL with methanol referred as stock solution of concentration 30i??i??g/ mL. Aliquots of 1 mL, 2 mL, 3 mL, 4 mL and 5 mL of Letter | Sample Templates stock solution were pipetted out into separate 10 mL volumetric flask. Release Form Template | Resume. The volume was made up to the mark with methanol.

This results in samples of 3, 6, 9, 12 and 15 ‘g/mL concentration, respectively. The absorbance of prepared solution of Resume / Cv + Cover Letter Set 01 telmisartan in 8+ Records Form Template methanol was measured at 296.5 nm in Shimadzu UV-1700 spectrophotometer against an appropriate blank. Preparation of calibration curve in HCl buffer (pH 1.2): Exact procedure was followed as described above by using HCl buffer (pH 1.2) instead of methanol. The absorbance was recorded at 296 nm. 4.2.6. solublity of telmisartain in different medium. Solubility of telmisartain was determine in the different medium by heand shaking method. 3.3 Formulation 76. 4.3.1 identification of microemulsion region : Determine solubility of telmisartain in Card Template Vectors | Download Free Art different -2 medium then select three medium orange oil as oil, PEG 400 as surfactant and Form Template Language tween 80 as co-surfactant. Micro-emulsion region was identify by constructing pseudo ternary phase diagram with the help of different proportion of surfactant and co-surfactant (1:1, 2:1, 3:1). They are mix with oils at different proportion (1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, 9:1) and the complete mixture was titrate with water and noted the equbliurem point.

At which point the mixture will show clear. 4.3.2 preparation of liquid SMEDDS: Due to the higher microemulsion region in the 3:1 proportion (surfactant:co-surfctant) was selected for the preparation of LSEDDS. 1. Required amount of / Cv + Cover By PEG 400 and tween 80 was take and mix with the help of stirrer until they compatibly mix. 2. Aquaretly weight telmisartain and 8+ Records Template take required amount of Confidentiality Agreement orange oil and 8+ Records Release Form Template mix il. 3. Drug mixture place on water bath until drug completely dissolve in oil. 4. Both the mixture are mix togather on 250+ Vectors Free the magnatic stirrer untill they are compleately mix and 8+ Records form a isotropic mixture. 5. Store in the glass bottle.

Table 4.3 chemical requirements. Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg. 4.4 CHARACTERIZATION :76-77. 4.4.1 stability study :76. heating cooling cycle: for the stability study of Job Appointment Letter | Sample Templates LSEDDS pass six cycle between hot and cool temperature (40c-450c) with storing not less then 48hrs at each temp. not seen any type of phase sapration. centrifugation test: After passing heating cooling cycle it would be pass with centrifugation test. The sample of LSEDDS placed in centrifuge for 30min and show any type of Form | Resume precipitation. Set 01. If not seen it would be go to the next stability test. freeze thaw cycle: This test is again at cool and hot temperature (-210C to | Resume +250C) 48 hrs at Thank You Letter, each temp. If the LSEDDS pass all the stability parameter means the system becomes stable. 4.4.2 cloud point measurement : 76-77. Liquid SMEDDS was diluted with distilled water at 250 times LSEDDS : distill water(1:250), placed in a water bath and its temperature was increased slowely-2.

Cloud point was measured as the temperature at which there was a sudden appearance of cloudiness visually. 4.4.3 solubility test .77-78. Solubility of LSEDDS was determine at buffer solution at 1.2ph, 7.4ph, and methanol by using standard paddle type dissolution test apparatus. Preparation of Release Form Template | Resume HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in a 200 mL volumetric flask then 85 mL of Manager Resumes [] HCl solution (0.2 M) was added in the flask and volume was adjusted to 200 mL with distilled water. Buffer pH 7.4: Mix 50 mI of solution containing 1.944 per cent w/v ofsodium acetate and Release Form 2.946 per cent w/v of barbitone sodium with 50.5 mI of 0.1 M hydrochloric acid, add 20 mI of an 8.5 per cent w/v solution of sodium chloride and dilute with water to 250 mI.

4.4.4 efficiency of self emulsification :76-77. Using USP- type-II dissolution test apparatus (Veego VDA-8DR). 1 mL of Student And Human Chart Liquid SMEDDS was added drop wise to 8+ Records Release | Resume 200 ml of 250+ Vectors | Download Free Vector Art 0.1 N HCl at 37i??i??C. agitate using by using standard stainless at 8+ Records Template, rotating paddle at Resume + Cover Letter By, 60 rpm. SMEDDS assessed visually according to 8+ Records Release Form Template | Resume the rate of emulsification and final appearance of the emulsion. 4.4.5 Robustness to dilution :76. it can be studied by by diluting LSEDDS at different concentration with distill wate. 1. Prepare HCL buffer solution PH 7.4, PH 1.2. 2. Prepare dilution with both the Resumes [], solution at following concentration. 3. Store for 12 hrs.

4. Observe any type of phase saperation or pracipation. 4.4.6 % transmittance :76. For the determination of % transmittance take. 1. 8+ Records Release Language. 1ml of Manager Resumes LSEDDS and diluted till 100ml with distilled water. 2. Scan this sample in the uv spectroscopy. 3. observe any type of turbidity and % transmittance. 4.4.7 Dye solubility test : 76. This test can be perform for the conformation of oil in 8+ Records Release Language water nature of LSEDDS by 250+ Business Card Vectors | Download Vector Art observing sopntenious dispersion. 1. Take water soluble dye and sufficient quantity of LSEDDS. 2. Rapidly incorporate dye into the system. 4.4.8. in vitro drug release:76-77.

In vitro dissolution study of LSEDDS using type -2 dissolution test apparatus in buffer solution ph 1.2, ph 7.4 at 8+ Records Release Template, 370 c. Drug release in buffer solution at 1.2 PH :- 1. Prepare buffer solution 1.2 PH by Business Card Template | Download Vector the help of indian pharmacopeia. 2. Fill in the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in Release Template Language the apparatus. Start the assumbaly. 4. Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min. 5. Job Appointment Letter Templates. The all sample was filtered with whatmant filter paper.

And dilute upto 10ml. 6. If there concentration is high then take again 1ml to all the samples and and dilute again upto 10ml. 7. The sample was scan into the uv spectroscopy at 296nm. Drug release in 8+ Records Release Form | Resume Language buffer solution at 7.4 PH :- 1. Prepare buffer solution 7.4 PH by the help of indian pharmacopeia. 2. Fill in the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in the apparatus. Start the Manager Resumes, assumbaly. 4. Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min.

5. The all sample was filtered with whatmant filter paper. Template Language. And dilute upto 10ml. 6. If there concentration is high then take again 1ml to all the samples and and dilute again upto 10ml. 7. The sample was scan into the uv spectroscopy at 296nm. 4.4.9 drug contant:76-77-78-79. drug content of LSEDDS should be determine by diluting 1 ml sample of Student Health / Organization LSEDDS with distill water.

Take there absorbance in uv-spectroscopy at296nm. 1. Take 1ml sample of 8+ Records Release Language LSEDDS and dilute with distill water upto 100ml. 2. If the concentration of sample was high then furthers 1ml sample dilute with distill water upto 10ml. 3. Scan this sample in uv-spactroscopy. 4. Calculate there percentage by 250+ Free Vector Art the help of leaner line equation. RESULT AND DISCUSSION. Table 5.1: Melting point of telmisartan.

S. No. 8+ Records Release Form | Resume Language. Melting point Result. 5.1 LOSS ON DRYING: The results were within the acceptable limit which is 0.5%. Table 5.2: Loss on drying. S.No. 250+ Business Card Template | Download Free Art. Time (min) Weight (mg) Difference in weight (mg)

Total difference 2.9. 5.2 FTIR spectroscopy: FT-IR spectra of pure drug telmisartan and its solid dispersion which are shown in figure 7.1 and Form | Resume 7.4. There was not any significant interaction found between drug and carriers which confirms the stability of drug in the formulation. Table 5.3: Major peaks observed in Student And Human / Organization Chart FTIR spectrum of telmisartan. S. No.

Standard peak Observed peak Comments. 1. 3059.1cm-1 3080 cm-1 C-H stretching (aromatic) 2. Release Template Language. 2958.8-2868.15 cm-1 2870-2738.92 cm-1 C-H stretching (aliphatic) 3. 1697.36 cm-1 1687.71 cm-1 C=O stretching. 5. 1521.84-1458.18 cm-1 1462.04 C=C stretching ring. Figure 5.1: FT-IR spectra of pure telmisartan.

5.4 LEMDA MAX OF TELMISARTAIN IN DIFFERENT SOLVENT SYSTEM : Table 5.4: Solvent systems, their parameters and Resumes values. S.No. Solvent system Parameters Values. 1. Methanol i??i??max 296.5 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.050x + 0.007. Regression coefficient (R2) 0.999. 2. Buffer 7.4 i??i??max 298 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.043x + 0.004.

Regression coefficient (R2) 0.999. 3. HCl buffer (pH 1.2) i??i??max 296 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.046x + 0.007. Regression coefficient (R2) 0.999. 5.5 CALIBRATION CURVE OF TELMISARTAN IN DIFFERENT SOLVENT SYSTEM. Table 5.5: Calibration curve of telmisartan in HCl buffer pH 7.4 and HCl buffer pH 1.2 at ‘max 298 nm and 296 respectively. S.No. Concentration (i??i??g/mL) HCl buffer pH 7.4 HCl buffer pH 1.2. Absorbance Regressed Absorbance Absorbance Regressed Absorbance.

2. 3 0.139 0.133 0.153 0.145. 3. 6 0.270 0.262 0.294 0.283. 4. 9 0.401 0.391 0.423 0.421. 5. 12 0.537 0.520 0.567 0.559. 6. 15 0.657 0.649 0.706 0.697. S.No.

Concentration (i??i??g/mL) Methanol. Absorbance Regressed Absorbance. Table 5.6: Calibration curve of telmisartan in 8+ Records Release Template | Resume Language methanol at Job Appointment Letter, ‘max 296.5 nm. Figure 5.2: Calibration curve of telmisartan in buffer 7.4 ph at 298 nm. Figure 5.3: Calibration curve of 8+ Records Release Form Template | Resume telmisartan in HCl buffer pH 1.2 at 296 nm. Figure 5.4: Calibration curve of telmisartan in methanol at 296.5 nm.

5.6 SOLUBILITY OF TELMISARTAIN : Table 5.7: solubility of telmisartain in different medium. S.NO. MEDIUM SOLUBILITY. 1. Water Insoluble. 2. Hcl Springly soluble. 3. Methanol soluble. 5. PEG400 Soluble. 6. Tween 80 Springly soluble.

7. Tween 20 Springly soluble. 8. Span 80 Springly soluble. 5.7 IDENTIFICATION OF MICRO-EMULSION REGION BY PREPAPE PSUDO TERATORY PHASE DIGRAM. In this formulation preportion of surfactant and co surfactant is 1:1. Table 5.8: identification of micro-emulsion region. SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is Mutual Agreement, 2:1. Table 5.9: identification of micro-emulsion region.

SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is 3:1. Table 5.10: identification of micro-emulsion region. Smix : OIL END POINT. Result- Best micromulsion was found to be In formulation 3 at 5:5 proportion of oil and Form | Resume Language mixture of surfactant and co-surfactant denoted as smi. 5.8 FORMULATION OF LIQUID-SELF EMULSIFYING DRUG DELIVERY SYSTEM (LSEDDS). 5.8.1 chemical requirement: Table 5.11: chemicals requirements . Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg/2gm. 5.9 EVALUATION OF LSEDDS.

5.9.1 stability study. Physical stability was important parameter in the emulsion system it can be affected the performance of the system, it can be occurs due to the precipitation of drug. Due to Job Appointment Letter the poor stability of system bioavability of drug also affected. For the thermodynamic stability study of LSEDDS was perform by following perameater. 1. 8+ Records Release Form Template Language. Heating cooling cycle.

2. Centrifugation test. 3. Freeze thaw cycle. When system can not show any type of Mutual – Sample phase separation during heating cooling cycle then syatem can be tested in the centrifugation for the drug pricipation then apply freeze thaw cycle for the stress test. heating cooling cycle : 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation.

450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. Table 5.12: six cycle of Release Form | Resume heating cooling temp. Result ‘ not seen any type of phase saperation. Centrifugation test:

Result- LSEDDS was centrifuge for Thank 30 min there was not seen any type of precipitation and phase saperation. freeze thaw cycle. Table 5.13: three cycle of -210c to +250c. Cool temp. No change.

Hot temp. | Resume. No change. Cool temp. No change. Hot temp. No change. Cool temp. No change. Hot temp. No change. 5.9.2 cloud point measurement. Table 5.14: Cloud point. Sample Cloud point.

Result- cloud point of this emulsion system was found to be more then 860c. which indicates that our LSEDDS was stable at the physiological temperature without any risk of phase separation. 5.9.3 solubility study: Table 5.15: solubility of LSEDDS. Medium Solubility time. Buffer solution PH 1.2 Less than 5min. Buffer solution PH Less than 5min. 0.1 N HCL Less than 5min.

Result ‘ solubility of this system was found to be less than 5min which indicates that the formulation also use in the sustain release drug delivery system with maximum bioavability. 5.9.4 Efficiency of Mutual – Sample self-emulsification. Sample Efficiency of 8+ Records Template | Resume Language LSEDDS. 1 Less than 1min. 2 Less than 1min. 3 Less than 1min. Result ‘ this system rapidly form micro emulsion with in 1min it was clear and appearance was slightly blush. 5.9.5 Robustness to dilution : Table 5.15: dilution with different solvents. Concentration Water Buffer solution.

PH 1.2 Buffer solution. 50 times No change No change No change. 100 times No change No change No change. 500 times No change No change No change. 1000 times No change No change No change. Result ‘ in the robustness dilution not seen any type of phase separation and pracipation. Result- % trasmittance of this system was found to be 93.5. 5.9.7. dye solubility test.

Result- type of emulsion was conform by using dye solubility test in which a water soluble colourfull dye rapid incorporate in the LSEDDS and observe. Which indicates that the continuous phase in this system is water. so it was conform that the Manager [], LSEDDS was o/w micro emulsion. 5.9.8 in-vitro drug release profile. drug release in buffer solution PH1.2. Table 5.16 in-vitro drug release of SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 7.35 42.43. 15 min 11.63 61.36. 30 min 1.83 75.45.

45 min 18.64 83.33. 60 min 23.31 89.02. 90 min 27.15 95.26. 120 min 29.48 95.56. Figure 7.4 commulative % drug release of SEDDS and plain telmisartain in PH 1.2. drug release in buffer solution PH 7.4.

Table 5.17 in-vitro drug release of SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 11.38 47.39. 15 min 14.92 54.43. 30 min 19.61 73.13. 45 min 24.48 81.68. 60 min 28.29 90.83. 90 min 32.62 96.54. 120 min 33.46 98.12.

Figure 7.6 % commulative drug release of 8+ Records Language LSEDDS and plan telmisartain in PH 7.4. 5.9.9 drug content estimation. Table 5.18 drug content: The oral route is the most preferred method of administration of drugs. Resumes. Unfortunately, this route is not possible for 50% of currently marketed drug compounds due to their low solubility in water and low oral bioavailability. We study that self-emulsifying drug delivery system (SEDDS) can be used for the improvement of bioavailability of the 8+ Records Template | Resume Language, drug. In the preparation of this system containing with telmisartain as active pharmaceutical ingredient. To increase bioavailability solubility of Resume Set 01 By this drug. Due to poor solubility of Language telmisartain it cannot be formulate in Resume By the oral drug delivery system. But with the help of LSEDDS it’s possible to give telmisartain via oral drug delivery system.

After the complete study of 8+ Records Release Form Language LSEDDS we conclude that the system was very useful for the active drug molecules having poor solubility. 1. Yamamoto, J. and H. Tanaka, prepare neomatic phase in the liquid micro-emulsion. 250+ Template Vectors Vector. Nature (London), 2001. 409(6818): p. Form. 321-325. 2. Porter, C.J.H., N.L. Trevaskis, and W.N. Charman, Lipids and [] lipid-based formulations: for the optimization of drug delivery by oral route lipophilic drug. Nature Reviews Drug Discovery, 2007. 8+ Records Release Form Template | Resume. 6(3): p. 231-248.

3. Humberstone, A.J. and W.N. Charman, the oral drug delivery of poorly water soluble drugs. By forming a lipid based drug delivery system Advanced Drug Delivery Reviews, 1997. 25(1): p. 103-128. 4. 250+ Business Vectors Art. Kommuru, T.R., et al., Self-emulsifying drug delivery systems (SEDDS) of Release Form Template | Resume Language coenzyme Q10: formulation development and bioavailability assessment By forming a lipid based drug delivery system Advanced Drug Delivery. Int J Pharm, 2001. 212(2): p. 233-46. 5. Neslihan Gursoy, R. and S. Benita, Self-emulsifying drug delivery systems (SEDDS) for Letter Set 01 improved bioavability of poorly water soluble drug. Biomedicine Pharmacotherapy, 2004. 8+ Records Form | Resume Language. 58(3): p. 173-182.

6. Hauss, D.J., et al., prepare lipid based drug delivery system for poorly water soluble drug LTB4 inhibito to enhance there solubility as well as bioavability. Journal of Templates Pharmaceutical Sciences, 1998. 8+ Records Form | Resume. 87(2): p. 164-169. 7. Gao, P., et al., Development of a super saturable SEDDS (S-SEDDS) formulation of paclitaxel with improved there solubility that can enhance the bioavability of poorlt water soluble drug. 250+ Art. Journal of Pharmaceutical Sciences, 2003. Release Form Template | Resume Language. 92(12): p. Business Template Vector Art. 2386-2398. 8. 8+ Records Form Template. Patil Pradeep, R., et al., Bioavailability assessment of ketoprofen incorporated in gelled self-emulsifying formulation to improve the bioavability by using lipid based drug delivery systemAAPS PharmSciTech, 2005. 6(1): p. E9-13. 9. Kang, B.K., et al., Development of self-microemulsifying drug delivery system(SMEDDS) for Mutual Confidentiality Agreement improve the bioavability by Release | Resume Language using lipid based drug delivery. International Journal of Pharmaceutics, 2004. 274(1-2): p. 65-73.

10. Palamakula, A. and M.A. Khan, Self-Emulsifying Drug Delivery Systems (SEDDS) for improving bioavability of cytotoxicity of oils used in coenzyme Q10. International Journal of Pharmaceutics, 2004. 273(1-2): p. Resumes []. 63-73. 11.

Montenegro, L., et al., Effect of oil phase lipophilicity on in vitro drug release from o/w microemulsions with low surfactant content. Drug Development and Industrial Pharmacy, 2006. 32(5): p. 539-548. 12. Attama, A.A. and M.O.

Nkemnele, formulation and evaluation SEDDS using a biodegradable homolipid from 8+ Records Release Form | Resume, Capra hircus. International Journal of Pharmaceutics, 2005. 304(1-2): p. 4-10. 13. Djordjevic, L., M. Primorac, and M. Stupar, In vitro release of diclofenac diethylamide by using a lipid based microemulsion system. Mutual Confidentiality. International Journal of Pharmaceutics, 2005. 296(1-2): p. 73-79. 14. Agatonovic-Kustrin, S., et al., Prediction of a Stable Microemulsion Formulation for 8+ Records Form | Resume the Oral Delivery of a Combination of Antitubercular Drugs Using ANN Methodology. Pharmaceutical Research, 2003.

20(11): p. 1760-1765. 15. Taha, E.I. Student Health Chart. Response surface methodology for the development and evaluation of self nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Pharmaceutical Development and Form Template Technology, 2005. 10(3): p. 363-370. 16. Liu, Y., et al., Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin for improving bioavability of oridonin. Int.

J. Pharm., 2009. 365: p. 136-142. 17. Student Health Services / Organization Chart. Holm, R., I.H.M. Jensen, and J. Sonnergaard, Optimization of selfmicroemulsifying drug delivery systems using a d-optimal design and the desirability function. Drug. Dev. Ind.

Pharm., 2006. 32: p. 1025-1032. 18. 8+ Records Form Template | Resume. Porter, C.J.H., N.L. Trevaskis, and W.N. Charman, Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat. Rev. Thank You Letter. Drug Discov., 2007. 6: p. 231-248.

19.Gupta H, Bhandari D and Sharma A. Recent trends in oral drug delivery: a review. Recent Pat Drug Deliv Formul. 2009; 3(2): 162-73. 20. de Smidt PC, Campanero MA and Troconiz IF. Intestinal absorption of penclomedine from lipid vehicles in Release Form Template Language the conscious rat: contribution of emulsification versus digestibility. Int J Pharm.

2004; 270(1-2): 109-18. 21. Student And Human Services / Organization. O’Driscoll CM and Griffin BT. Biopharmaceutical challenges associated with drugs with low aqueous solubility–the potential impact of lipid-based formulations. Adv Drug Deliv Rev. 2008; 60(6): 617-24. 22. Koga K, Kusawake Y, Ito Y, Sugioka N, Shibata N and Takada K. 8+ Records Release Form Template | Resume. Enhancing mechanism of Labrasol on intestinal membrane permeability of the hydrophilic drug gentamicin sulfate. Eur J Pharm Biopharm. 2006; 64(1): 82-91. 23.

Sha X, Yan G, Wu Y, Li J and Fang X. Effect of Manager self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci. 2005; 24(5): 477-86. 24. 8+ Records Form Template | Resume. Sha XY and Manager Resumes Fang XL. Effect of self-microemulsifying system on cell tight junctions. Yao Xue Xue Bao. 2006; 41(1): 30-5. 25.

Yang S, Gursoy RN, Lambert G and 8+ Records Release Template Benita S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm Res. 2004; 21(2): 261-70. 26. Constantinides PP and Wasan KM. Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies. J Pharm Sci. 2007; 96(2): 235-48. 27. Charman WN, Rogge MC, Boddy AW and Berger BM.

Effect of Manager [] food and a monoglyceride emulsion formulation on danazol bioavailability. 8+ Records Template Language. J. / Cv + Cover Letter By Clin. Pharmacol. 1993; 33: 381’6. 28. Welling PG. Effects of food on drug absorption. Ann. 8+ Records Release Form. Rev. Nutr. 1996; 16 383’415.

29. Araya H, Tomita M and Hayashi M. Free. The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Release | Resume Language. Int J Pharm. 2005; 305(1-2): 61-74. 30. Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK and Ali M. Development and bioavailability assessment of ramipril nanoemulsion formulation. You Letter. Eur J Pharm Biopharm. 2007; 66(2): 227-43. 31.

Palin KJ, Phillips AJ and Ning A. The oral absorption of cefoxitin from oil and emulsion vehicles in rats. Int J Pharm. 1986; 33: 99-104. 32. Aungst BJ, Nguyen N, Rogers NJ, Rowe S, Hussain M, Shum L and White. Improved oral bioavailability of an HIV protease inhibitor using Gelucire 44/14 and 8+ Records | Resume Language Labrasol vehicles.

SBT Gattefosse 1994; 87: 49’54. 33. Saritha D, Penjuri SCB, Nagaraju R. Formulation and evaluation of self emulsifying drug delivery system (SEDDS) of Indomethacin, International Journal of Research in Pharmacy and Science 2014; 4(2): 17-23. 34. Job Appointment Templates. Damineni S Penjuri S C B, and Nagaraju R. formulation and evaluation of self emulsifying drug delivery system (SEDDS) of ibuprofen, International Journal of Pharmaceutical science and research 2014; 5(8): 3511-3519. 35. . Release Form Template | Resume. Kumar S, Kumar S G, Kumar P, Sharma R. Student Health And Human Chart. self-Emulsifying Drug Delivery Systems (SEDDS) for 8+ Records Form Template Language Oral Delivery of Lipid Based Formulations, African Journal of Basic Applied Sciences 2012; 4 (1): 07-11. 36. Reddy M S, Reddy N S, Reddy SM. solubility Enhancement of Poorly Water Soluble Drug Efavirenz by Solid Self Emulsifying Drug Delivery Systems, International Journal of Job Appointment Templates Pharma Research Review, 2014; 3(4): 20-28. 37. Amrutkar C, Salunkhe K, Chaudhari S. study on self nano emulsifying drug delivery system of poorly water soluble drug rosuvastatin calcium, World Journal of 8+ Records | Resume Pharmaceutical Research 2014; 3(4): 2137-2151.

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68. Student Health Services. Agarwal V., Siddiqui A., Ali H., Nazzal S. (2000), Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS), International Journal of Pharmaceutics, 366: 44-52. 69. Kim H. J., Yoon K. A., Hahn M., Park E. 8+ Records Form | Resume Language. S., Chi S. C., (2000), Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone, Drug Dev Ind Pharm., 26(5): 523-529. 70. Letter | Sample. Chen G. L., Lee F. Y. (1996), Validation of botanical method for Verapamil by high performance liquid chromatography, J Med Sci, 17(1): 16-23. 71.

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